THC Ministry :: Community Forum Index
AustraliaBasqueBulgariaCanadaChinaEgyptFranceGreeceIcelandIndiaIndonesiaIrelandJamaicaJapanJordanLatviaMexicoNetherlandsNew Zealand
NorwaySpainPakistanLebanonPeruPolandPeurto RicoRomaniaRussiaSingaporeSouth AfricaSudanSwedenThailandTurkeyUnited KingdomUSAUzbekistan
Clinical Studies Begin to Replace Emotion with Evidence.

 
Post new topic   Reply to topic    THC Ministry :: Community Forum Index -> Cannabis news
View previous topic :: View next topic  
Author Message
Ferre
Cannabis Sacrament Minister.
Cannabis Sacrament Minister.


Joined: 14 Apr 2003
Posts: 2701
Location: Amsterdam

PostPosted: Sun Sep 07, 2003 9:15 pm    Post subject: Clinical Studies Begin to Replace Emotion with Evidence. Reply with quote

By Daniel DeNoon, WebMD Medical News

A sea change in science is slowly turning the tide of the medical marijuana debate.

For hundreds of years, marijuana has been used to treat a wide variety of illnesses. But the herb has been illegal throughout the modern era of scientific medical research. Patients swear the drug works to relieve pain, prevent seizures, and counteract the nausea-inducing effects of cancer chemotherapy. But by today's standards, there's no definitive proof that this is so.

Why not? Nearly all U.S.-funded marijuana research has looked for harmful effects from using marijuana as a recreational drug. Meanwhile, there's been little money -- and huge regulatory hurdles -- for studies of marijuana's benefits. That's now changing despite the fact that marijuana remains classed as a Schedule I drug -- a dangerous compound with no medical uses.

Why now? Evidence is beginning to break down the wall of emotion preventing medical marijuana research.

Expert Panels, Breakthrough Findings

It was never clear exactly how marijuana -- which scientists call cannabis -- exerted its euphoria-inducing effects on the brain. Then, in the 1980s, a series of breakthrough studies showed that the body actually makes its own cannabis-like compounds -- cannabinoids.

Why are they there? That question led to the discovery that the body has an entire system based on cannabinoid signals. The signals seem to calm down overexcited nerve cells, says Igor Grant, MD, professor of psychiatry and director of the Center for Medicinal Cannabis Research (CMCR) at the University of California, San Diego.

"It may be the cannabinoid systems -- this is a crude example -- but I think of them as our internal shock absorbers," Grant tells WebMD. "They are circuits that prevent overexcitability, kind of dampers. If that's correct, there are going to be a number of medical applications. For example, I wouldn't be surprised if there were applications for epilepsy and other types of seizures."

Grant isn't the only scientist excited by these possibilities.

In 1997, a National Institutes of Health expert panel concluded that more needs to be known about possible marijuana benefits. In 1999, the Institute of Medicine agreed. It pointed to several areas crying out for clinical marijuana research, notes CMCR co-director Andrew Mattison, PhD.

"There are cannabinoid receptor systems in the brain areas that regulate motion -- and, in retrospect, we know that people with multiple sclerosis and difficulty with spasticity sometimes use medicinal cannabis. That is one of the Institute of Medicine indications for clinical trials," Mattison tells WebMD.

"There is a cannabinoid receptor for pain, another site that modulates appetite -- there's going to be a wealth of basic science research that will hopefully have clinical and practical applications to many different medical indications."

Early Clinical Findings Support More Research

Although funded through 2003 and only at various University of California locations by the California state legislature, the CMCR has, by default, become the national clearinghouse for marijuana research.

The CMCR works closely with state and federal regulators - including the FDA, the Drug Enforcement Administration, and the National Institute on Drug Abuse (the only legal source of marijuana in the U.S.). CMCR provides funds for clinical trials of marijuana. It's won national praise for holding its investigators to the highest scientific standards.

Even before the CMCR was up and running, one stubborn researcher managed to launch a marijuana clinical trial. Donald Abrams, MD, now chief of hematology/oncology at San Francisco General Hospital, is best known for being one of the first doctors to recognize and treat the illness that came to be known as AIDS. AIDS patients have long used marijuana to fight the terrible wasting the disease causes. It's also been said to help an extremely painful condition known as peripheral neuropathy -- a painful nerve disease that has few effective treatments.

Abrams wanted to get federal approval to see whether marijuana really works for this condition. But years of effort proved futile in the face of opposition by federal agencies. Finally, Abrams had a brainstorm. Marijuana affects the immune system. It was just possible that the drug was making patients worse, not better. He submitted a research proposal to look for a harmful effect of marijuana -- and finally won the approval he sought.

The results of that trial appear in the August 19 issue of Annals of Internal Medicine. And they contradict previous studies done in the test tube and with lab animals.

"Much of the published work on marijuana and the immune system is focused on animals and in vitro studies," Abrams tells WebMD. "And, well, if you flood a lot of petri dishes with THC [the active ingredient in marijuana], the immune-cell cultures are going to do poorly.

"In our clinical trial we really didn't see any detriment to the immune system from smoking cannabis. Basically we saw no perturbation of HIV viral load, no detriment to the immune system, and no significant interaction with anti-HIV drugs."

With CMCR funds, Abrams is now doing his peripheral neuropathy study. And he's well on the way to launching a study to see whether adding marijuana to other pain drugs can give relief to dying cancer patients. Overall, the CMCR now has five full-fledged clinical trials under way, which will enroll some 450 patients.

Doctors' Shifting Attitudes on Medical Marijuana

In the last week of July 2003, Medscape -- WebMD's web site for medical professionals -- asked its members what they thought about medical marijuana. It wasn't a scientific poll, although a member's vote is counted only once. Still, the results were surprising. There was a huge response. Three out of four doctors -- and nine out of 10 nurses -- said they favored decriminalization of marijuana for medical uses.

Is it a real trend? Abrams thinks so, but warns that long-held attitudes are slow to change.

"I was pretty much the Lone Ranger of medical marijuana research a few years ago. But not now," he says. "Still, researchers are wary of marijuana research. They feel their reputation may be tainted. And they may be right. For several years I've been invited to do grand rounds at a local hospital in the Bay area. Last year they disinvited me, and I hear it was because of my marijuana research. I've been disinvited from other speaking engagements, too."

"I think these attitudes will change over time -- but it will be slow-going," Mattison says. "Dr. Abrams' comment is typical. People in the medical profession may chuckle at marijuana research and think it is not a bona fide area for scientific investigation. But that will change as the science becomes more clear and more understandable and there are, at some point, some practical applications."

One surprising source of support is moral encouragement from conservative politicians.

"We get a number of stories from elected officials who say, 'Look, I am not for legalization of marijuana. But my sick mother, relative, son, is using it and doing so much better, -- there must be something in it,'" Mattison says.

"A number of people have friends where medical therapies aren't working, and cannabis provided relief from spasticity, pain, nausea, or vomiting. That is turning some opinions and helping people let go of the stereotypical notion that medical marijuana is for potheads."

The CMCR has put aside enough money to complete all its currently approved clinical trials. But the California budget crisis means no more money this year -- at least. Does this mean that clinical research into medical marijuana is over? Grant doesn't think so.

"I think that even if our center runs on hard times, the ball has started rolling," he says. "Clinicians and neuroscientists have an interest in this. There is gong to be more research, and more clinical work, whether we do it or not. Eventually, I foresee NIH [National Institutes of Health] clinical trials. That's my hunch."

A Final Warning

What's changing is the attitude toward investigating possible marijuana benefits. This means more and more doctors are keeping an open mind -- not jumping to the conclusion that the drug will be all things to all people.

"I don't know what the answers will be," Grant says. "The data that are out there suggest there will be some positive applications for marijuana. If I had to bet, I'd say there will be some applications useful for patients in the future."

But, he warns, the opposite could easily be true. The one sure thing about medical research is that it doesn't always provide the answers people expect.

"The caution is that, in the movement toward making marijuana available to patients with no other treatment options, there is the assumption that it is in fact useful. We have to be careful about that," Grant says. "It may be useful for some things, but not useful for others. And if patients take things that are not useful, they may be harming themselves. I urge them to be cautious instead of jumping on the bandwagon and maybe hurting themselves."

SOURCES: Annals of Internal Medicine, August 19, 2003; vol 139: pp 258-266. Vastag, B. Journal of the American Medical Association, August 20, 2003; vol 290: pp 877-879. Workshop on the Medical Utility of Marijuana, National Institutes of Health, 1997. Marijuana and Medicine: Assessing the Science Base, Institute of Medicine, 1999. Igor Grant, MD, professor of psychiatry and director, Center for Medicinal Cannabis Research, University of California, San Diego. Andrew Mattison, PhD, co-director of the Center for Medicinal Cannabis Research, University of California, San Diego. Donald Abrams, MD, professor of clinical medicine, University of California, San Francisco, and chief of hematology/oncology, San Francisco General Hospital.

Note: Clinical Studies Begin to Replace Emotion with Evidence.

_________________
I hereby declare Peace on war!
Please read the Board Rules and Posting, and you
Back to top
View user's profile Send private message Send e-mail Visit poster's website Yahoo Messenger MSN Messenger
sara
Cannabis Sacrament Minister
Cannabis Sacrament Minister


Joined: 29 May 2003
Posts: 68
Location: Breukelen,Netherlands

PostPosted: Mon Sep 08, 2003 10:29 pm    Post subject: Reply with quote

Hi Ferre and all,

That guy Vastag,B JAMA journalist interviewed me last year about Iboga.
I told him then that I was giving pot as part of a methadone heroin detox program I developed together with Carl Waltenburg ,
he wrote in that artical (dec.2002) that I was using various herbs.
Tell me what do you think? why didn't he write Cannabis.
is it because someone else who is MD would like to have an American
reaserch at an american university who would say two years from now,
We have done a reaserch and we have our name on the world literature,
we are MD. and we tell you.
why wouldn't they just ask me I tell them It works that why people come here, and I don't not need to be at the university reaserch to see and say
that it works. what a stupid political game.

I tell ye, I have been working with Iboga and cannabis for the last four years and had done more the 120 treatments by now, this guy cOld Mr. Marc Emery asked me to come work for him because he wanted to copy my treatment which he did , now he said he treated 28 people since last year, but then he didn't do nothing he has people to do it for him while he is taking the credits . look at Maps.org
at Ibogaine in the world, nothing is writen about the Netherlands
why ? Do you think that Maps doesn't know about me? or are they blind ?
no they are not. Emery who got rich from selling Cannabis seeds coming from Amsterdam ,( Waar anders? ) can give a good donation to Maps.Org
and get the credits just like that. And when I ask mr. Rick Dublin
what is this hypocrisy about , I wrote to him that in the first place I told Emery
assitant and himself how to do the treatment , so how come the Netherland is not mentioned? he didn't answer,

look few years from now , we are going to do a reseach how usful cannabis can be when detox from heroin/ methadone in combination with Iboga.
I tell you that now. Do I get a Nobel price for it ? sure not , I'm not an american MD at the university, so why should they?

Only Mr. Emery would buy himself a Nobel price for a reasrch That has been done before him , by me.

hemp Holland Hemp! wake up ! we have done the reseach, Cannabis works and we know it.

Sara Glatt
_________________
shine the light.
Back to top
View user's profile Send private message Visit poster's website
Ferre
Cannabis Sacrament Minister.
Cannabis Sacrament Minister.


Joined: 14 Apr 2003
Posts: 2701
Location: Amsterdam

PostPosted: Tue Sep 09, 2003 12:20 am    Post subject: Reply with quote

applause stars ©Sara Glatt stars yourock

I agree with you sarah, I guess it's a matter of ambition and greed somewhere.. Also I guess it's a matter of getting into the right channels to get publicity, America is not the center of the world, get recognition in Europe to start with, you already have it here at the ministry and from more than 120 people you cured.
You are doing a great job, I trust you'll get the recognition, it maybe take some time but it's also the "strong" people that made a difference in our world. I believe you're one of them. Do you have a website? there's ways to get a totally free website that can give you more publicity. and I'm sure we have many members (check the usersgroups) who can help you, even with promoting of your site.

_________________
I hereby declare Peace on war!
Please read the Board Rules and Posting, and you
Back to top
View user's profile Send private message Send e-mail Visit poster's website Yahoo Messenger MSN Messenger
sara
Cannabis Sacrament Minister
Cannabis Sacrament Minister


Joined: 29 May 2003
Posts: 68
Location: Breukelen,Netherlands

PostPosted: Tue Sep 09, 2003 7:41 am    Post subject: Reply with quote

It is a matter of power and control, ambition and greed.

I didn't cure 120 people , I just had 120 treatments some people
for spiritual journey, and some for sex crack coc, speedballs, speed,
anti depressents , tranqulizers,bi-polar medication.
not all wanted to be cured but wanted to try iboga, an have a good time in Amsterdam.
I can say the 90% got clean at least for two years.some needed a repeated treatment.
30% of the treatment I have given away for no charge.

Anyways, I had an interview with HET PAROL two weeks ago,
_________________
shine the light.
Back to top
View user's profile Send private message Visit poster's website
Display posts from previous:   
Post new topic   Reply to topic    THC Ministry :: Community Forum Index -> Cannabis news All times are GMT
Page 1 of 1

 
Jump to:  
You cannot post new topics in this forum
You cannot reply to topics in this forum
You cannot edit your posts in this forum
You cannot delete your posts in this forum
You cannot vote in polls in this forum
Public forum Public Forum Members only Members only forum Members Group Members Group

THC-Light skin designed for Amsterdam Cannabis Ministry by JuggoPop of Touchstonestudio.com
Powered by phpBB 2.0.11 | THC Ministry Members | Cannabis Religion | Sacrament | Forum html archives | Site Map |
ScriptWiz.com phpbb HTML Archiver - Created by ScriptWiz.com and released by Skinz.org